Myocardial extracellular volume fraction and myocardial fibrosis by cmr in patients with severe aortic stenosis
نویسندگان
چکیده
Background Severe aortic stenosis (AS) induces diffuse interstitial myocardial fibrosis (MF). CMR late gadolinium enhancement (LGE) technique is useful to detect focal MF. The amount of MF is associated with worse long-term prognosis after aortic valve replacement surgery (AVR). Measurements of T1 relaxation times before and after gadolinium administration allow determination of myocardial extracellular volume fraction (ECV) in order to assess diffuse MF. In this study we investigated ECV and LGE prevalence and extent in severe AS, and compare them to left ventricular (LV), aortic valve (AV) function and MF by biopsy.
منابع مشابه
Reappraising myocardial fibrosis in severe aortic stenosis: an invasive and non-invasive study in 133 patients.
Aims To investigate myocardial fibrosis (MF) in a large series of severe aortic stenosis (AS) patients using invasive biopsy and non-invasive imaging. Methods and results One hundred thirty-three patients with severe, symptomatic AS accepted for surgical aortic valve replacement underwent cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) and extracellular volume f...
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متن کاملBolus administration T1 mapping as a marker of interstitial myocardial fibrosis in severe aortic stenosis
Background Aortic stenosis (AS) is associated with increased interstitial myocardial fibrosis (IMF). This is detectable by cardiovascular magnetic resonance (CMR) after gadolinium infusion. T1-mapping-derived partition coefficients (l) and extracellular volume fractions (Ve) have also been shown to correlate with IMF after a simple bolus administration of gadolinium. We hypothesized that the l ...
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عنوان ژورنال:
دوره 17 شماره
صفحات -
تاریخ انتشار 2015